الفهرس 
EpidemiologyOnly 14 pages are availabe for public view
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Abstract
Ulcerative colitis (UC) is a chronic inflammatory disease that
primarily affects the colonic mucosa. Ulcers from in the inner lining
or mucosa of colon and rectum often resulting in diarrhea, blood and
pus. The inflammation is usually most sever in the sigmoid and
rectum and usually diminishes higher in the colon. The course of the
disease is generally relapsing–remitting, with patients experiencing
few or no gastrointestinal symptoms in between symptomatic
flareups (relapses). (Stephen, 2006).
Several antibodies have been associated with Ulcerative Colitis, the 2
most comprehensively studied being auto-antibodies to neutrophils
(atypical perinuclear anti-neutrophil cytoplasmic antibodies) and
anti-Saccharomyces cerevisiae antibodies. (Xavier, 2006).
The present study, we assessed the prevalence of p-ANCA and ASCA
and their diagnostic value for Ulcerative Colitis patients. The study
was performed in Benha University Hospital, Department of Internal
Medicine.
The present study included 42 patients diagnosed as Ulcerative Colitis
patients (20 Males and 22 Females). Their ages ranged between
(18 -65) years and Main age (37.59) years. Diagnosis of Ulcerative
Colitis was confirmed by the clinical picture, colonoscopy and by
histo-pathological examination of colonic mucosal biopsies. 23 of
patients are active and 19 quiescent.
Sera from 14 healthy hospital stuff members, without any history of
gastrointestinal disease or familial history of Inflammatory Bowel
Disease, age, sex matched were included as control group (6 Males
and 8 Females).
All members of the Group 1: Control group, and Group 2:
Ulcerative Colitis patients group are investigated for both p-ANCA
and ASCA Test.
Summary and Conclusion
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Our results indicate that p-ANCA sensitivity were 64%, specificity
94%, and positive predictive value 84% (P-value < 0.05) for diagnosis
of Ulcerative Colitis. That means p-ANCA is highly specific
moderate sensitive test cant used as screening test for Ulcerative
Colitis but as a highly specific diagnostic test for Ulcerative
Colitis.
Our results indicate that ASCA sensitivity were 12%, specificity 50%,
and positive predictive value 11% (P-value > 0.05) for diagnosis of
Ulcerative Colitis. That means ASCA test is Non-Significant for
diagnosis of Ulcerative Colitis but good negative to exclude
Ulcerative Colitis.
The combination of these two testes p-ANAC and ASCA, sensitivity
DROPped by approximately 10%, became 54% as would we expected,
but specificity still 94%, and yielding a very high positive predictive
value 95% for this combination.
Our results indicate that p-ANCA is strongly associated with
Ulcerative Colitis and ASCA are not.