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Abstract
We conducted a study to examine to what extent the endothelium cells
are injured in glomerulonephritis patients. Forty-five GN patients were divided
in three groups; first was GN with normal kidney function, second GN renal
impairment and third was GN on haemodialysis. vWF and CRP levels were
measured in all three groups and compared to a healthy control group. All
patients had biopsy proven GN, non- diabetic and normotesive. Venous samples
were collected and laboratory investigations were made. vWF and CRP levels
were measured using the ELISA. Our results have proven that endothelial injury
is early in the glomerular disease, even before renal impairment occurs. Results
from the second group have proven that renal impairment further deteriorates
the endothelial cell injury. The hemodialysis group study revealed remarkable
findings. First, CRF independently caused endothelial damage. Second, we
concluded that haemodialysis improves endothelial function in
glomerulonephritis patients but, this remains to be proven with a prospective
study.