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Abstract We conducted a study to examine to what extent the endothelium cells are injured in glomerulonephritis patients. Forty-five GN patients were divided in three groups; first was GN with normal kidney function, second GN renal impairment and third was GN on haemodialysis. vWF and CRP levels were measured in all three groups and compared to a healthy control group. All patients had biopsy proven GN, non- diabetic and normotesive. Venous samples were collected and laboratory investigations were made. vWF and CRP levels were measured using the ELISA. Our results have proven that endothelial injury is early in the glomerular disease, even before renal impairment occurs. Results from the second group have proven that renal impairment further deteriorates the endothelial cell injury. The hemodialysis group study revealed remarkable findings. First, CRF independently caused endothelial damage. Second, we concluded that haemodialysis improves endothelial function in glomerulonephritis patients but, this remains to be proven with a prospective study. |