الفهرس | Only 14 pages are availabe for public view |
Abstract Diabetes mellitu a group of metabolic di orders characterized by hyperglycemia and in the majority of long standing patients by mieroangiopathic a cular complication especially in the eye, kidney and nervou ystem (G(J~’;ltet at. 2003), The de elopment 0 type 2 diabere i as ociated with psucreati pcell dysfunction occurring together with insulin re i ranee. Type 2 manife re 11elf clinically in individual who 10 the ability to produce . ufficient quantitie of insulin to maintain nonnogl ’cemia in the face of insulin re istance (Katltl’in-w!aetllel’ et (11.; 2001). Apoptosi i a mode of progrmnmed cell death. ransdu tion of apoptotic signals result in.cellular uicide. The Fa i a widely 0 eurring apoprotic signal receptor molecule expr sed b almost any type ofcells. It is also relea ed III a oluble circulating form (Fas (Papathflfff11a sogio« et al., 2000 ((11(/ Co . .onet al., 2005). e Teml rudies olltyp 2 diabetic patient ha e ound either normal Or reduced ~-<:ell rna when compared with normal non-diabetic individual (Sempollx el uf. 2001) .. The mechani m underlying. this decrease in ~-cell ma s i increased ~-cell apoprosi _ Accumulating evidence suggests that apoptosis ’is the main form of ~-cell death in type 2 diabete (Butler ef ai., 2003) Under diabetic condition _ reactive ox)rgen sp ecie (ROS) are pr duced mainly rhrough the gl cati n reaction. \. hich occur in ariou tis ues and may play a role ill the development’ of complications in |