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Abstract Magnesium has been used as a therapeqtic agent for several hundred years. Its earliest use was as a cathartic, for which it is still used most commonly. Magnesium-rich waters have been thought to be beneficial since the early 17th century. The dangers of excessive magnesium intake were also recognized, with the first case of magnesium poisoning recorded in 1891 when 4 ounces of magnesium salts caused complete muscular paralysis in a 35-yr-oId woman.(l) There are a large number of theoretical benefits of magnesium therapy, from laxative and antacid therapy to cytoprotection for organs prepared for transplantation. |