الفهرس 
Pathogenesis & risk factors of venous thrombosisOnly 14 pages are availabe for public view
 |  | from | 101 |  |  |
| | | from | 101 | | |
Abstract
Venous thromboembolic disease (VTE) is a common condition, with clinically recognized deep vein thrombosis (DVT). Patients with chronic liver diseases are at risk of developing venous thrombosis.
Portal vein thrombosis was detected in 7% and DVT in 5.5%.
This could be attributed to defects in production of the natural anticoagulants: Antithrombin III, Protein C and Protein S.
In fact, in cirrhotic livers obstruction of small intrahepatic portal hepatic veins is observed almost invaiability.
Thus changes in the composition of the blood towards a hypercoagulable state in combination with changes in the endothelium of intrahepatic vessels and/or in intrahepatic blood flow, which often develop in chronic liver disease with fibrosis, certainly favour the development of thrombosis in intrahepatic veins.