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Abstract ’;:’”friSt :~ .a: ana ea the t Lc to be d_scovered was coczir.e,a~d a_kalc~d p~~$ent in ~he leaves of eryth~cxyton ccva . tl”.e purified a”l”aloid ~4aS fi-:-st isolated and named by llbert N!emanc’s. ’rhe int.roduc’;;ion of: cocaine in 1884 by Ka::-L Koller ae a local sur-race anaesthetic for the eye’ :;>epresented an important t andmarec in starting t.he h::’stor-y of regianal anaesthesia (Niemann. 1860). Other lnves .iga tor. ex tended Koller’ s ob ss rV3.t’i.On, :n 1B84 Hall de6cr~bed ~cv he blacked a cu~aneouS branch of the ulnar nerve, to his o’:·m fOl”9.::”m. Also Halsted o_ocked Hall’s supra~~:cnlear nerve and removed and adjoinlng congenital cystic tumou~ (Burke. 1884). tn 90, i3:-aUtl introoducec the ter-m conduction anaes> thu:La and left t ha t the use of” ep1neph~ine rendered conduc iCI1 anaesthesia in othe:o pa::”t$ c.:’ the body as e fective as that 1n an extremity. In the s,arne year Braun published a textbook on l oca I anaesthesia giving the detailed description c~ the technique for ever-y ~egion {Braun, 1914). In 1869 the observation tha subcutaneOuS inJect10n |