الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Numerous reports document the role of vascular adhesion molecules in the
development and progression of atherosclerosis. E-selectin plays a role in the early stages
of vascular disease by facilitating the attachment of leukocytes to the endothelium.
Polymorphism in the E-selectin gene leading to a replacement of serine by arginine at
position 128 has been associated with premature coronary artery disease. Intercellular
adhesion molecule-1 (ICAM-1) plays a crucial role in lymphocyte migration and
activation, and is considered important in the pathogenesis of atherosclerosis. The aim of
the present study was to evaluate the association between gene polymorphism of Eselectin
& ICAM-1 and peripheral arterial occlusive disease (PAOD) in Egyptian. We
investigated 2 mutations, namely S128R in E-selectin and K469E in ICAM-1 in 52
patients with PAOD and 30 control subjects using polymerase chain reaction–restriction
fragment length polymorphism (PCR-RFLP) analysis in an Egyptian population. Patients
were classified into 31 diabetic and 21 non diabetic subjects.