الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The obtained results in this investigation represent
the influence of prolactin on plasma level of different
hormones with metabolic activity including GH,
TSH, cortisol, glucagon and insulin in male, female
mices and virgin as well the uptake of C14-Galactose,
C14-Valine and C14-Arginine in different tissues of
mices.
Four logaxismic doses of prolactin (10, 59, 144
and 350 ~/kg.B.W.) was performed and sampling ( for
hormonal assay) were 30 min 24 hr s , and 72 hr. following
the i.p. application of prolactin, but sampling (for
the C14-Galactose, C14-Valine ~nd c14_Arginine) was
24 hr. following the a~~inisteration of the different
prolactin doses.
The results were, then, stastistically analysed
and illustrated in 27 tables and 9 figures.
The gained results can be summarised in the following
items:
Effect on GH
a) In immature male mice:
The lowest dose of prolactin (10 ~g) induced a
significant increase in the level of GH but only )0
min. after the application. whole after 24 and 72 hr
as well the other doses of prolactin (59. 144 + 350 pg)
after 30 min, 24 and 12 hr induced. In contrast a
significant decrease in the plasma level of GR.
b) In immature female mice:
The 10 pg dose of prolactin decreased the level . of GH of )0 min. and 24 hr but increased it significantly
after 72 hr the other higher doses of prolactin resulted
in a significant decrease of GH in the plasma after 30
min. 24 and 72 hr but with tendenoy to some increase
wi th the time.
c) In virgin:
The lowest doses (10, 59 pg) of prolactin showed
a significant decrease in GH level of plasma after 30
min. in case of 10 pg after )0 min. and also 24 hr in
case of 59 vg. Meanwhile, the significant decreasing
after 144 p.g and 350 pg after 30 min 24 hr 72 hr.
II. Effect on TSH:
a) In immature male:
Meanwhile, the decreasing in TSH hormone level in
plasma after 30 min. of from lowest doses of prolactin,
then TSH level increased after 24, 72 hr but the highest
doses of prolactin also decrease in TSH level after 30
min. and also increased the levels of TSH hormone after
72 hr.
b) In immature female mice:
There are a relation with time between dose and
,
a significant decreasing in the TSH level of plasma.
c) In virgin:
The level- of TSH in plasma following different
doses of prolactin in virgin showed a bell-shaped
character in relation with time i.e. it decreased
slgniflcantelly after 30 min. as well after 72 brs.
while ~ncreased significantly after 24 bra.
Effect of cortisol
a) In immature male:
The plasma level of cortisol increased driastioally
following all doses of prolactin (except the lowest dose
after 30 min.) This increase was proportional with the
dose of prolactin.
b) In immature female
All doses of prolactin induced also a dramatic
increase of cortisol in plasma.
c) In virgin:
Except the highest dose of prolactin (350 pg) after
30 min., there was and a significant increase of plasma
cortisol level following all doses of prolactin, but not
proportional with the dose as descriped in immature male
and female.
Effect of Glucagon:
a) In immature male:
The level of glucagon on plasma was variable according
to the dose and time after application. It has
been DROP significantly after 30 min. from the application
of the 10 }1g of prolactin while elevated significantly
after 24 hr meanwhile, the 59 pg dose induced a significant
decrease of glucagon level after the different
tested times; but the third dose (144 pg) of prolactin
increased glucagon level after 30 min. and decreased it
significantly after 72 hr. on the other hand, the 350 pe
dose resulted in a significant increase after )0 min.
and 24 hr but decreased that after 72 hI.
b) Immature female
While the lowest dose decreased the glucagon . level in plasma only after 12 hr the 59 pg as well
144 pg doses of PRL. Showed the draping as soon as
)0 min. following the application the highest dose
(350 pg) of prolactin resulted in a significant increase
after 30 min. and a significant decrease after 12 hr.
c) In virgin
In contrast of the results obtained in immature
male and females, the glucagon level in plasma showed
a marked and significant decrease following all doses
of prolactin.