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Abstract
Leptin is a 16-kDa polypeptide hormone that is mainly, but not exclusively, produced in adipose tissue and plays a key satiety role in regulating food intake and energy expenditure.
The kidneys play a key role in the systemic elimination of circulating leptin. Leptin is not metabolized by the kidney but is excreted as an intact protein.
The purpose of this study that included 45 children (25 children with nephrotic syndrome and 20 healthy children as a control group) was to study the changes in serum and urine leptin concentrations in children with nephrotic syndrome during relapse and remission and to find out whether those children have proportionate changes in serum and urine leptin levels to known disturbances in lipid metabolism.
The present study revealed that in children with nephrotic syndrome the increased leptin loss in the urine was accompanied by a decrease in its serum levels and there was a positive linear correlation between leptin and albumin levels in the serum and between leptin and protein levels in the urine.