الفهرس Only 14 pages are availabe for public view
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Abstract
The thesis is prefaced by a brief account on biological activities of indole derivatives, synthesis of 2-acylindoles and N-alkylation of indole nucleus. The reported analgesic and anti-inflammatory activity of many indole derivatives and different aryl-heteroaryl ketones initiate the research in our laboratories to design and synthesize certain new 2-aroylindoles to be investigated as potential anti-inflammatory, analgesic and antipyretic agents. The intermediates n-alkyl-o-aminoketone (4a-d) were synthesized through three successive steps: First, protection of 0-aminoketones from polyalkylation by tosylation. Second, alkylation of N-tosyl-o-aminoketones (2a,b) using alkyl halide and anhydrous potassium carbonate. Third, hydrolysis of N-alkyl-N-tosyl-o-aminoketones (3a-d)using 80% sulfuric acid at 155-65°C.