الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
Summary and Conclusion
In this study we investigated the role of the FF A in the pathogesis of insulin resistance accompanied to obesity through the using L-camitine as a FF A oxidation stimulant and bromocriptine as a FF A oxidation inhibitor. Also, we studied the [feet of aloes extract, beza:q.brate and L-camitine compared to
etformin in the management of type 2 diabetes mellitus ssoeiated with obesity.
Fasting glucose, fasting insulin, insulin resistance, total d FF A acids, total cholesterol, triglycerides, low-density ’poprotein cholesterol, high-density lipoprotein cholesterol and ral glucose tolerance in obese diabetic rats were determined.
Also, in this study we investigated the role of the tested rugs in the protection against the development of type 2 iabetes mellitus by coadministration of these drugs along the igh fat diet during the induction of obesity.
In addition we investigated the mechanism by which the sted drugs induced its actions. Also, we investigated the effect f withdrawal of the used drugs for ten days on the oral glucose lerance in obese rats with continuous feeding on high fat diet d the effect of withdrawal of high fat diet for ten days on oral licase tolerance of obese rats.
e main findin can be summarized as follows:
Induction of obesity in adult male rats significantly creased the serum levels of glucose, insulin, total and free ttY acids, total cholesterol, triglycerides, LDL-C and insulin
istance. On the other hand obesity has led to significant
decrease in the serum level of HDL-C, glucose tolerance and utilization.
. Oral administration of metformin (270mg/kg) for 30 days to obese rats induced a significant reduction in the serum levels of glucose, insulin, total and free fatty acids, total cholesterol, triglycerides, LDL-C and insulin resistance. However, it significantly increased the glucose tolerance and the serum level of HDL-C. Also administration of metformin to obese rats which are on high fat diet prevented the progressive increase in the body weight of these rats.
\. Oral administration of aloes extract (500 mg/kg) for 30 days induced a significant reduction in the serum level of glucose, insulin, total and free fatty acids, total cholesterol, triglycerides, LDL-C and insulin resistance. However it significantly increased the glucose tolerance and the serum level of HDL-C. Also administration of aloes extract to obese rats which are on high fat diet prevented the progressive increase in the body weight of these rats.
Oral administration of bezafibrate (54mg/kg) to obese rats for 30 days induced a significant reduction in the serum level of glucose, insulin, total and free fatty acids, total cholesterol, triglycerides, LDL-C and insulin resistance. However it significantly increased the glucose tolerance and the serum level of HDL-C. Administration of bezafibrate to obese rats, which are on high fat diet, prevented the progressive increase in the body weight of these rats.
Oral administration of L-Camitine (270 mg/kg) to obese rats induced a significant reduction in the serum level of glucose, insulin, total and free fatty acids, total cholesterol, triglycerides, LDL-C and insulin resistance. However it significantly increased the glucose tolerance and the serum level of HDL-C. Administrations of L-camitine to obese rats, which are on high fat diet, prevented the progressive increase in the body weight of these rats.