الفهرس 
coverOnly 14 pages are availabe for public view
 |  | from | 173 |  |  |
| | | from | 173 | | |
Abstract
Membranous glomerulonephritis (MGN) is a slowly progressive disease. 85% of MGN cases are classified as primary membranous glomerulonephritis; that is to say, the cause of the disease is idiopathic & the remainder of cases are secondary. The disease is more common in adults, the male to female ratio is approximately 3 : 1. Patients with MGN manifest as nephrotic syndrome (heavy proteinuria 3.5 gm or more per 24 h.), and the consequences of protein loss (hypoalbuminemia, hyperlipidemia & oedema). Other patients may be asymptomatic and may be diagnosed during screening or urine analysis as having proteinuria. A definitive diagnosis of MGN requires a renal biopsy.
The aim of this work is to study retrospectively the cases of MGN with emphasis on the electron microscopic picture (type of deposite) in relation to pathologic and laboratory findings. Three methods of diagnosis were available (LM, Immunologic study & EM). Clinical sheets and laboratory tests performed were tabulated, renal biopsy records were reexamined for all cases. Thirty patients were studied (seventeen males and thirteen females), twenty were classified as idiopathic MGN and ten were classified as secondary MGN.
The idiopathic cases divided into two subtypes based on their different patterns of subepithelial deposits seen on EM; eight were diagnosed as homogeneous type with a synchronous phase of electron dense deposits, and with large dense deposits (deep subgroup) while twelve were diagnosed as heterogeneous type with various phases of dense deposits, according to (Yokoyama et al; 2002).