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Abstract
There was evidence that foetal leptin may play a role in fetal growth and development, with a positive correlation between umbilical cord blood leptin concentration and newborn weight body mass index, and arm fat. The major determinant of fetal leptin concentration is the development of adipose tissue and the accumulation of fat mass (Ogueh et al., 2000).
Osteocalcin is a bone specific protein that binds to the surface of bone mineral crystal. Small amounts of newly synthesized osteocaltin are released into circulation and have been well correlated with histological indices of osteoblastic activity and bone formation rate (Patterson-Buckendah et al., 2001).
The present study aimed to investigate the effect of leptin hormone regulating the fatty tissue reserves and osteocacin as a marker of bone formation on the physical growth of newborn babies.
Subjects included 81 neonates divided into 40 full term (16 females and 24 males) and 41 preterm (19 females and 22 males) babies, born at Ain Shams University Hospital, Obstetrics and Gynaecology Department. Umbilical cord blood samples were analysed for serum leptin and serum osteocalcin.