الفهرس 
MAGNESIUM PHYSIOLOGYOnly 14 pages are availabe for public view
 |  | from | 146 |  |  |
| | | from | 146 | | |
Abstract
The magnesium ion blocks the ion channel of N-methyl-D-aspartate (NMDA) receptor in a voltage-dependent fashion (Nowak et al., 1984). Also, increased extracellular magnesium concentration in vitro cause a non-competitive NMDA blockade (Harrison and Simmonds, 1985). Several studies have shown that intrathecal administration of magnesium sulfate alone produced a small degree of antinociception or no nociception but resulted in potentiated antinociception when magnesium was coadministrated intrathecally with morphine (Kroin et al., 2000). However, magnesium transference from blood to Cerebrospinal Fluid (CSF) across the Blood-Brain Barrier (BBB) in unclear in normal humans. In one study, when the propofal infusion rate was held constant and the fentanyl dose was adjusted to hemodynamic endpoints, opioid requirements were reduced (Koining et al., 1998). This result suggests that the effect of magnesium on anaesthesia should be studied further.
Accordingly, the aim of this work is to study the perioperative effects of continuous intravenous administration of magnesium sulfate. To be more precise, two main aspects are included in this study. Firstly, intraoperative effects of magnesium sulfate on stress response and anaesthetics requirements. Secondly, its postoperative analgesic effects when combined with regional analgesia without opioid administration.