الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
Colorectal cancer comprises 11% of all cancer incidence 13% of all cancer mortality in the united states. However , the worldwide age incidence is rare before the age of 40 and then increases significantly in each succeeding decade. In conclusion , these results indicate that increased cox-2 expression may relate a tumor cell autonomous role for COX-2 in the promotion of tumorigenesis , to growth and malignant transformation of adenomas and may play an important role in the progression of colorectal adenomatous change. Accordingly , our results taken together with those of others prompted us to believe that assessment of COX-2 level in colorectal cancer may be used as a marker to select not only high-risk patients group for recurrence and offer them more frequent follow-up but also patients who may likely benefit from COX-2 inhibitors as adjuvant therapy either alone or in combination with established anti-cancer drugs.