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Abstract
Migraine is a common, chronic, multifactorial neurovascular disorder typically characterized by recurrent attacks of disabling headache and autonomic nervous system dysfunction. Migraine is a painful and disabling disorder that imposes substantial burden on individual sufferers and society as a whole.
The present study was carried out to clarify hemodynamic changes in the cerebral blood vessels by transcranial Doppler (TCD) as well as probable structural brain lesions using magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) in young adult migraineurs. The included subjects of our study were divided into two groups:
Patients group [Group I]:
Forty migraineous patients were selected; 32 females (80%) and 8 males (20%); fulfilling the International Headache Society (IHS) diagnostic criteria for migraine. Age of patients was selected to be ranged from 20- 40 years with mean age of 32.48 ± 6.19 years.
Patients were further classified into 2 subgroups:
Group 1a: Migraine without aura (26 patients).
Group 1b: Migraine with aura (14 patients). Control group [Group II].
Twenty age and sex matched normal volunteers; 13 females and 7 males; were included with mean age 31.75±5.68 years. The included patients were subjected to the following:
1) Full history taking with special stress on history of headache.
2) The Migraine Disability Assessment Score (MIDAS).
3) Thorough general and neurological assessment.
4) Laboratory investigations including:
a) Complete blood count (CBC).
b) Fasting blood sugar.
c) Kidney function tests.
d) Liver function tests.
e) Erythrocyte sedimentation rate (ESR).
f) Others: selected according to the clinical condition of every case.
5) Transcranial Doppler Ultrasonography.
6) Magnetic Resonance Imaging.
7) Magnetic Resonance Angiography.