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Abstract
Adhesion molecules are involved in leukocyte rolling firm adhesion, transmigration and as such play a role in inflammatory disorders as well as a variety of other pathophysiological processes.
ICAM-1 is members of the immunoglobulin gene superfamily of adhesion molecules.
ICAM-1 is expressed on leucocytes, fibroblast, epithelial cells and endothelial cells.
Lymphocyte adhesion to endothelium, extravasation and adhesion to hepatocytes are mediated by adhesion molecules and constitute important steps in the liver inflammation due to chronic HCV.
This study was carried in Biochemistry Department with the cooperation with Internal Medical Department Faculty of Medicine, Zagazig University.
Sixty individuals were included in this study. All of them were males, their ages ranged from 30-50 years. They were classified into four groups: control group, healthy smokers, HCV non smokers and HCV smokers.
Blood sample was taken from each individual and subjected for centrifugation for separation of serum samples for estimation of:
- Total, direct bilirubin, Albumin, total protein, GPT, GOT, ALP, urea, uric acid, creatinine levels by colorimetric method.
- ICAM-1 by ELISA
Also, urine samples were collected for estimation of urinary cotinine by RIA.
The results of this work revealed that:-
1) Serum ICAM-1 levels were significantly higher in healthy smokers, HCV non smokers, and HCV smokers compared to control.
2) No significant difference was observed in serum ICAM-1 levels of healthy smokers compared to group HCV non smokers.
3) Urinary cotinine levels were significantly higher in healthy smokers HCV smokers compared to control group.
4) No significant difference was observed in urinary cotinine level when HCV non smokers compared to control group.
5) No significant correlation was detected between serum ICAM-1 level and urinary cotinine in all groups.