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Abstract Hepatitis C virus infection is a global health problem. Recently, HCV infection was concluded to be the main cause of chronic liver diseases in Egypt, where this infection is largely associated with schistosomiasis, which has been claimed to be an important risk factor for HCV infection. However, the type of relationship between HCV infection and schistosomiasis has been the subject of much controversy. The present study was conducted in order to: 1- Estimate HCV seropositivity rate among school children aged 6-15 years. 2- Investigate the association between HCV and schistosomiasis among the studied groups. 3- Study the different demographic (Age, Sex, …..), socioeconomic (education, occupation, ……) and other factors that may affect such association. Out of 800 school children aged 6-15 years old who were screened for the presence of Schistosoma mansoni eggs in stool using the modified Kato Katz thick foecal smear technique, 100 of the Schistosoma mansoni positive school children were recruited in this study as group I (50 students from primary school and another 50 from preparatory school). Group II comprised another students matched with group I for age and sex and proved by stool and urine examination to be negative for schistosoma eggs. All studied school children were submitted to the following: - Filling a predesigned detailed questionnaire sheet. - Full clinical examination for abdomen (liver, spleen, ….). - Stool analysis using the modified Kato Katz thick foecal smear (three slides were prepared from each stool sample) and urine analysis for group II using Medi-test for schistosomiasis. - Estimation of ALT levels and serodiagnosis of anti-HCV antibodies using the ELISA second generation and RIBA confirmatory tests. Data collected were coded, tabulated and analysed. The statistical analysis of the data revealed the following results: 1- Male students accounted for 58 while the percentage of the females was 42. |