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Abstract
In recent years, low molecular weight heparins (LMWHs) have
attracted increasing scientific and clinical interest as anti thrombotic
drugs. Their clinical investigations have mainly been focused on the
prevention of deep vein thrombosis (DVT) following surgery.
LMWHs have a different pharmacological profile from unfractionated
heparin. They have a longer half-life, higher bio-availability and have
been reported to have anti thrombotic effects when administered
subcutaneously once daily. Because of these properties LMWHs were
considered to be promising anti thrombotic agents for the prevention
of thrombo-embolic diseases.
The present study was performed to investigate the efficacy and
safety of LMWH (Fraxiparine) relative to that of the low dose
regimen of heparin (5000 units subcutaneously twice daily), and
detect the association between venous thrombo-embolism and
anaesthetic technique.
The study included 90 adult patients class I and 11 ASA status,
admitted into orthopaedic department, Zagazig
University Hospital. Patients who were scheduled to have hip
replacement (Total or hem i-arthroplasty), kneearthroplasty or femur
neck repair were eligible to participate in the study. A full medical
history was taken including a detailed case report giving particular
attention to bleeding and clotting disorders. A physical examination
including an examination for pre-existing thrombo-embolic diseases