الفهرس 
AcknowledgmentOnly 14 pages are availabe for public view
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Abstract
It comprises a review of some official drugs, possessing purine or pyrimidine nucleus and used in anticancer and antiviral therapy. A review of the literature focusing on the pharmacological action of purine and pyrimidine analogues and or bioisosteres is included.
Research objectives
This part deals with the chemical and biological bases on which the synthesized compounds were selected. It was also planned to screen some selected compounds for their possible biological action.
Discussion
In this part, the various methods applied for the synthesis of the intermediate and final compounds, including pyrazolo[4,3-d]pyrimidin-7-ones, pyrido[2,3-d]pyrimidin-4-ones and quinoxalines, are discussed. The different strategic methodologies to achieve certain compounds have been detailed. Certain illustrative reaction mechanisms are included. The chemical structures assigned to the prepared compounds were substantiated by elemental analyses, IR, 1H-NMR, 13C-NMR and Mass Spectral data. The discussion is represented in nine synthetic schemes.
Experimental
In this part, details of the experimental applied techniques throughout the present work are described. It also includes the physical characters, microanalyses and the spectral data that support the assigned structures of the new synthesized compounds. Selected representative IR, 1H-NMR, 13C-NMR and Mass spectra for selected intermediates and target compounds are illustrated throughout this part. The experimental part comprised nine synthetic schemes relevant to those of the discussion.
Biological studies
This part describes the biological testing of some selected compounds:
i. Antimicrobial screening
The in vitro antimicrobial screening of the prepared compounds against three representative types of bacteria S. aureus, as a Gram-positive bacteria, and E. coli and P. aerugenosa as Gram-negative bacteria. They were also evaluated for their in vitro antifungal activity against C. albicans. The results of these screening are discussed.