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Abstract
Protein energy malnutrition is multifactorial in origin, the underlyingcauses include inadequate food intake, together with metabolic abnormalities,poor absorption of food and recurrent infections. The pathogenesis of suchconditions is due, in part, to oxidative stress resulting from imbalance betweeninappropriate production of free radicals and deficiency of antioxidants either ofendogenous origin or exogenous origin.
The rise in free radicals associated with antioxidant deficiency results intissue damage. The pathogenesis of edema and anemia commonly found inchildren with protein energy malnutrition has been suggested to be caused byoxidative stress and the process of lipid peroxidation.
This work was designed to evaluate the role of oxidant -antioxidantimbalance in the pathogenesis of protein energy malnutrition diseases.
This study was carried out in Medical Biochemistry and PediatricDepartments, Faculty of Medicine, Zagazig University. It included 45 infantsand children divided into 3 group:
- Group 1: compromised 15 healthy child not suffering from any diseasethat may interfere with our study.
- Group 2 : involved 15 patients diagnosed as having marasmus.- Group 3: included 15 patients diagnosed as having kwashiorkor.