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Abstract CHF is an important and growing public health problem and the cause of substantial morbidity and mortality. Cytokines have been identified as a major player in the pathogenesis and the functional status of patients with HF. CHF is a state of inflammatory immune activation characterized by elevated circulating levels of TNF-a. IL- 10 is a potent anti- inflammatory cytokine that inhibits TNF-a production and lessens endotoxin bioactivity. The balance between TNF-cc and IL-b is important for immune homeostasis maintenance. Exuberant production of TNF-u contributes to overwhelming inflammatory response and tissue damage. But, commonly, increase in TNF-a is counterbalanced by simultaneous synthesis of an anti-inflammatory cytokine IL-b, which suppresses production of many activating and regulatory mediators. The aim of this study is to evaluate the serum level of the proinflammatory cytokine group (TNF-CL) and the anti-inflammatory one (IL10) in patients with Cl-IF. This study included 44 subjects, classified into: group I including 11 patients with acute congestive heart failure (ACHF); group II including 18 patients with chrohic congestive heart failure (CCHF), and control group including 15 apparently healthy volunteers. |