الفهرس 
Physico - Chemical Properties of PropofolOnly 14 pages are availabe for public view
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Abstract
The intravenous anesthetics are important group of drugs that have changed the course of general anesthesia. The most important members in clinical use nowadays are thiopentone, benzodiazepmes, ketamine HCL, neuroleptanesthetics and lastly propofol.
Propofol is a new addition to the field of intravenous anesthesia. Being a water-insoluble agent, it was previously solubilized in Cremphor El. This formulation had many side effects, so it is prepared now as an oil emulsion formulation.
Propofol is a rapidly acting anesthetic with a short duration of action. It is rapidly metabolized by the body mainly in the liver with additional extrahepatic sites.
Propofol produces its rapid smoot. i anesthetic action with a mild analgesia and without any antanalgesic effect. It has a dose- related respiratory and cardiovascular depressant action. Propofol produces a significant fall in intracranial and intraocular pressures. It does not depress the adrenal stress response and does not have porphyrinogenic activity. Being irritant to veins, it may cause pain on injection.
Propofol can be used for induction and maintenance of anesthesia and as a sedative in subanesthetic doses. It produces a smooth rapid induction which may be accompanied by a decrease in arterial blood pressure with little change in the heart rate.