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Abstract
HCC is the fifth most common neoplasm & 3rd common cause of cancer-related deaths all over the world.
Telomeres are special functional complex of specific DNA sequence repeats at the end of eukaryotic chromosomes and these terminal structures have an essential role in protecting chromosomes from end-to end fusion & DNA degradation.
Telomerase is a ribo-nucleoprotein enzyme that synthesizes telomeric DNA and adds this sequence to chromosomal ends.
Thereby, it prevents telomere shortening and consequently protects the chromosomes from DNA degradation, end-to-end fusion, rearrangements and chromosomal loss.
Telomerase activity has been found not only in germ line cells and stem cells, but also in various cancer specimens and almost in all human cancer including breast, bladder, ovary, prostate, colon, liver, stomach, brain and others.
The aim of this work is to study the expression of hTERT mRNA in blood of patients with HCC and its correlation to the level of serum AFP,|to detect its possible role as an early marker of HCC in susceptible cases.
This study was conducted on 44 patients complaining of HCC and J1D, selected from the HCC clinics and inpatient department of National (iver Institute Hospital, Menoufiya University.
In addition, 12 apparently althy individuals of comparable age and gender were taken as a control oup. They were divided into groups as follows