الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
Just as a metabolic disturbance, diabetes mellitus (DM) affect most body tissues, they affect oral structures.(l) The carriage of yeasts, notably. Candida species in the oral cavity is frequently reported to be increased in patients with DM. In addition chronic atrophic oral candidosis has been reported to be more prevalent among diabetic individuals compared with non-diabetic controls. . Since disease is frequently preceded by colonization, it is important to identify factors which predispose to colonization of diabetic patients oral cavity by Candida species. So this work aimed to study of different factors affecting the oral colonization of yeasts, notably Candia albicans (c. albicans) among diabetic patients. . The present work included 193 participants attending the out patient dental clinic of the Faculty of Dentistry for orodental treatment. Alexandria University, of them 147 were diabetic patients, out of them 49 were IDDM type and 99 of them were NlDM type, the rest 45 were diabetic participants and they were considered as control group. Detailed history, including personal history about age, sex, occupation, medical history including a history of medication with particular reference to antibiotics or/and corticosteroids containing preparations within the past 2 months, in addition to social history particularly of alcohol intake and smoking habit, and full dental history including diabetes related dental complications as mobility of teethes and oral inflammation. Methods and frequencies of dental cleaning, and history of denture wearing if present including ”. .. methods of cleaning and weather it is lefted out of mouth at night or not. Oral examination was kindly carried out by the out..patient dentist and oral hygiene was assessed according to the simplified j , oral hygiene index (OtlI-S) which measured the surface area of the tooth covered by debris and calculus. All subjects were requested to remove out their dentures, if present, the palatal mucosa and mucosa of the crest of the upper ridge were swabed and were directly inoculated on divided plates of Sabourauds dextrose agar (SDA) then were kept in a thermally adjusted ice box up to 15-20 QC, then all subjects were requested to rinse their mouth thoroughly for 60s with 10 ml sterile phosphate buffered saline (p.B.S), then requested to return them back in 10 ml sterile plasic container and then kept in the ice box until reaching the laboratory. 2 ml venous blood sample were obtained from all subjects for AB &0 blood grouping, determination of secretor status, and if they are diabetic glycosylated haemoglobin (lib) as well as determination of random blood glucose level were done.. In the laboratory the oral rinse samples were centrifuged, concentrated and the sediment was resuspended in 1 ml sterile (P.B.S), then a loop.full with fIammed sterilized standard loop 0.02 ml was streaked on a SDA plate to obtain concentrated oral rinse culture (C.R.C) which then incubated aerobically at 37°C for 48 hr together with the swabs plates, after 48 hr the CRC were counted and the colonies on the swabs plates were subjected to direct microscopic examination culturing on TOC medium, Germ tube test, cornmeal agar subculture and APT 20C system test for yeast colonies typing. The results showed that: . Diabetics were more prone to oral yeast colonization than non diabetic controls (51.35 and 20 respectively). . Effect of duration of diabetes mellitus disease results were doubtful due to the deficiency of medical records. . The poorly controlled diabetics as evaluated by glycosylated lib test were significantly more prone to oral yeast colonization than those of good glycaemic control (57