الفهرس 
Diabetes mellitusOnly 14 pages are availabe for public view
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Abstract
One of the most challenging health problems of the twenty-oneth century is
T2DM. It represents a significant disease burden on human beings, both in developed
and developing countries and now affects 285 million people all over the world.
T2DM is a complex metabolic disease that results from the combination of genetic
and environmental factors. Complication of diabetes are acute like diabetic
ketoacidosis and hyperglycemic hyperosmolar state and chronic like microvascular
complications (retinopathy, neuropathy, nephropathy) and macrovascular
complications.
The TCF7L2 gene, a high-mobility transcription factor, is considered one of
the important candidate genes for T2DM, playing a key role in blood-glucose
homeostasis and beta-cell function. This study aimed to study the TCF7L2
(rs7903146) gene polymorphism as a risk factor in the pathogenesis of T2DM and
diabetic complications. The study included 180 subjects. divided into 3 groups: Group
I: (Control Group), group II: (Diabetic without microvascular complications) and
group III: (Diabetic with microvascular complications).
Our results showed that:
There was no significant difference between controls, diabetic without
complications and diabetic with complications regarding age, sex and smoking.
However, BP was significantly higher in patient groups than controls. Also, BP
was significantly higher in diabetic with complications than diabetic without
complications.
Regarding BMI, it was significantly higher in patient groups than controls;
meanwhile, there was no significant difference between diabetic without
complications and diabetic with complications.
As regards FBG, 2 hr pp and HbA1c, were significantly higher in patient groups
than controls. Also diabetic with complications were significantly higher than
diabetic without complications. Meanwhile, there was no significant difference
between diabetic nephropathy, neuropathy and retinopathy groups.
Regarding creatinine and urea, they were significantly higher in DN than controls,
diabetic without complications, DPN and DR groups.