الفهرس 
Colorectal cancerOnly 14 pages are availabe for public view
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Abstract
Insulin is a major anabolic hormone which can stimulate both normal and malignant cell proliferation and its effect on cell proliferation is suggested to be with insulin-like growth factor 1 (IGF-1) stimulation. The study is designed to determine the relationship between Metabolic Syndrome as A Risk Factor for Colorectal Cancer.
A case control study was carried out on 200 MetS patients, 100 cases with colorectal cancer (CRC), and 100 IBS patients age and sex matched controls. The patients were randomly selected from those attending Gastroenterology Unit in Menoufia University Hospital, Kaefer El Sheikh University Hospital and Alexandria University Hospital, Egypt during the period from April 2019 to February 2020. This study was conducted on 200 subjects, divided into two groups:
group I: included100 patients with (CRC) with colorectal cancer diagnosed according to pathological results.
group II: included 100 IBS subjects of matched age and sex served.
All subjects of them were selected according to inclusion and exclusion criteria.
Inclusion criteria: Patients with MetS patients and colorectal cancer (CRC) diagnosed according to pathological results. Patients who did not receive radiotherapy, chemotherapy or other treatment for cancer before operation. All CRC presented as adenocarcinomas.
Exclusion criteria: Patients with acute inflammation, chronic liver and kidney damage, acromegaly, hyperthyroidism, polycystic ovary syndrome, cushing syndrome and other endocrine patients taking glucocorticoids, thyroid hormones, and other endocrine diseases, non-steroidal anti-inflammatory drugs, diuretics and other drugs that affect blood sugar and insulin. Familial adenomatous polyposis, hereditary nonpolyposis colorectal and anal cancer cases. Patients had a history of familial malignancy or other synchronous malignancy were excluded. All subjects were subjected to careful history taking, thorough clinical examination, laboratory examination and radiological investigations colonoscopy.