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Abstract
Diabetic nephropathy is a common microvascular complication of type 2 diabetes mellitus , it is a serious diabetic complication and accounts for much of its morbidity and mortality
Diabetic nephrophathy denotes a clinical condition characterized by persistent proteinuria , decline in rental glomerular function, hypertension , and progression to end stage rental disease
It is well established that the detection of microalbuminuria ina diabetic patient indicates the presence of glomerular involvement . There is also a tubular component as shown by the detection of rental tubular low molecular weight proteins in the urine such as alpha-1-microglobulin in the urine
This study aimed to assess the urinary alpha-11microglobulin and its relationship to microalbumin and glycemic control in patients with type 2 diabetes mellitus
The present study was carried out in the duration between March 2004 and December 2004, on patients recruited from the out-patient clinic of diabetes from El-Menoufya university hospital
The study included 25 patients with type 2 DM, 11 male and 14 female subjects aged from 35-61 years. In addition to 15 healthy subjects non-diabetes (6 males – 9 females) , their age ranged from 33-58 years as control group
All individuals were subjected to thorough history taking, full clinical examination, and laboratory investigations as follows: fasting blood glucose level & 2h . Postprandial level, Glycated Hb(HbA1C) , kindly function tests , Lipid profile, microalbumin in urine, ?1- microglobulin in urine and microalbumin/creatinine ratio , ?1- microalbumin/creatinine ratio were calculated at end