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تصفح المحتوي RDA
التصفح حسب الموضوعات
التصفح حسب اللغة
التصفح حسب الناشر
التصفح حسب تاريخ النشر
التصفح حسب مكان النشر
التصفح حسب المؤلفين
تصفح الهيئات
التصفح المؤتمرات
التصفح حسب نوع المادة
التصفح حسب العلاقة بالعمل
تم العثور علي : 58
 تم العثور علي : 58
  
 
إعادة البحث

Articles 2023
   

Book 2004
ISBN: 0534608132 ,2900534608131

Book 2004
ISBN: 0618333533

Book 2018.
ISBN: 9781138047037

Thesis 2017.
pharmacy - Abstract:
Historically
- plants have been used since ancient times and in folklore for the treatment of many diseases and illnesses including chronic diseases and cancer care. In recent years - plants have been getting more attention as drugs worldwide.
Achillea fragrantissima (Forssk.) Sch. Bip. is a desert plant which belongs to Asteraceae family and is known as Qaysūm in Arabic. We selected it as a member of family Asteraceae to be the plant under investigation. It grows in Sinai
- Egypt and is used in folk medicine by Bedouins for treatment of many diseases. In addition it has been tested for its anticancer activity. The broad aim of this thesis was to conduct a phytochemical investigation and biological confirmation of the plant Achillea fragrantissima (Forssk.) Sch. Bip. and its constituents as an anticancer agents illustrating their mechanism of action.
The initial part of this work focused on large scale extraction of the plant with different solvents
- bioactivity-guided fractionation led to the isolation of seven compounds followed by determination of the chemical nature of them. The isolated compounds are:
The known compounds Eupatilin 7- methyl ether (3)
- chrysosplenol D (4) - Cirsiliol (5) - β-Sitosterol-3-O-β-D-glucoside (6) and Cirsimaritin (7) while Piceol (1) and Veratric acid (2) are reported here for the first time from Achillea fragrantissima (Forssk.) Sch. Bip.
The second part of this work focused on evaluation of the in-vitro cytotoxic activity of the methanolic extract of A. fragrantissima (Forssk.) Sch. Bip
- its fractions and the isolated compounds 1 - 2 - 3 - 4 - 5 and 7 against different cell lines using the Sulpho-Rhodamine-B (SRB) assay. The extract - fractions (4 - 5) and the compounds 3 - 4 - 5 and 7 showed high cytotoxic activities when compared to appropriate reference drug (doxorubicin) and IC50 values (the concentrations of drug required to produce 50% inhibition of cell growth) were calculated for the isolated compounds.
The third part of this work focused on evaluation of the in-vivo antitumor activity of the methanolic extract of A. fragrantissima (Forssk.) Sch. Bip. and its isolated compounds 3
- 4 - 5 and 7 using Ehrlich’s Ascites Carcinoma (EAC) model in mice. A. fragrantissima (Forssk.) Sch. Bip. extract and its isolated compounds reduced the tumor weight compared to EAC-Control group. In addition - the compounds 3 - 7 treatments produced a dose dependent reduction in tumor weight. Determination of serum tumor necrosis factor – alpha (TNF-α) level highlighted that A. fragrantissima (Forssk.) Sch. Bip. extract and its isolated compounds significantly reduced its serum level compared to the EAC-Control group - where 3 - 5 - 7 groups produced a significant reduction in serum level of TNF-α compared to all other groups. Furthermore - A. fragrantissima (Forssk.) Sch. Bip. extract and the isolated compounds significantly increased the total antioxidant capacity (TAC) compared to EAC-Control especially compound 7. The histopathological examination revealed that A. fragrantissima (Forssk.) Sch. Bip. extract and its isolated compounds produced a better differentiation of tumor cells - with reduced nuclear pleomorphism and better formed tubular structures especially with high dose indicating the induction of apoptotic mechanism.
Finally
- an in silico study was performed as a step to elucidate the mechanism of the cytotoxic effect of the compounds isolated from A. fragrantissima (Forssk.) Sch. Bip - where the structure of cirsiliol (5) was docked into the active sites of the crystal structures of PI3K and Akt - two protein kinases that are significantly involved in prostate and breast cancer processes.
Key Words: Achillea fragrantissima (Forssk.) Sch. Bip
- anticancer - Ehrlich’s Ascites Carcinoma - Docking.
Aim of work:
Flora of Egypt especially in Sinai Peninsula is rich and diverse with medicinal and aromatic plants as well as herbs and spices. These plants have been used by local people in folk medicine for curing human and animal illnesses. The plants of genus Achillea as a part of Sinai Peninsula flora were and still a rich source of valuable natural products for treatment of many diseases; therefore
- this study was designed to fulfill:
1. Collection of the plant material from Sinai Peninsula in Egypt.
2. Bioactivity-guided fractionation to isolate active compounds using different chromatographic techniques.
3. Identification and structure elucidation of the isolated compounds
- using 1D NMR - 2D NMR and DEPT measurements.
4. In vitro cytotoxic and in vivo antitumor evaluations of the methanolic extract of Achillea fragrantissima (Forssk.) Sch. Bip. and its isolated compounds.
pharmacognosy

Book 1958

Book 1942

Thesis 2017.
Cardiothoracic Surgery.All patients in this study were subjected to the following:
1- Preoperative and postoperative ECG.
2- Preoperative and postoperative echocardiography.
3- Laboratory investigations:
 Routine investigations.
 Estimation of creatinine.
 Estimation of serum level of LDH
- Troponin and CK-MB.
 Estimation of serum level of NT-proBNP preoperative
and 24 hours after the operation.
- NT-Pro BNP was analyzed using a commercial NT-pro BNP
ELISA Kit (Biomedica
- Vienna - Austria).
4- Cardiopulmonary bypass time.
5- Aortic cross clamping time.
6- Requirement for cardiac support immediately after the operation
( drugs or intra-aortic balloon )
7- Duration of ventilation dependence
8- Duration of ICU and hospital stay.
9- Postoperative complications: (neurological- renal-pulmonarybleeding-
wound infection)
10- Operative mortality: includes in hospital death as well as death
within 30 days after surgery.The results of the present study:
-We found that there was significant relationship between NTproBNP
and need of inotropes after surgery.
-Also
- our results showed that there was statistically significant
difference between pre and postoperative NT-proBNP level.
Furthermore
- there was significant difference between preoperative
and postoperative LDH and CK-MB.
-In this study
- there was significant relationship between NT-proBNP
and duration of ventilation dependence.
-We also found significant relationship between NT-proBNP with
CBP time and aortic cross clamp time.
-As regards outcome
- there was significant relationship between NTproBNP
with prolonged ICU stay and hospitalization also
- there was
significant relationship between NT-proBNP and appearance of most
postoperative complications
- Cardiothoracic Surgery

Book 2009
ISBN: 9780073376318 ,0073376310 ,9780071283229 ,0071283226

Thesis 2010.


من 6
 







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