اختيار الموقع            تسجيل دخول
 

تصفح المحتوي RDA
التصفح حسب الموضوعات
التصفح حسب اللغة
التصفح حسب الناشر
التصفح حسب تاريخ النشر
التصفح حسب مكان النشر
التصفح حسب المؤلفين
تصفح الهيئات
التصفح المؤتمرات
التصفح حسب نوع المادة
التصفح حسب العلاقة بالعمل
تم العثور علي : 12
 تم العثور علي : 12
  
 
إعادة البحث

Thesis 2020

Thesis 2022.

Thesis 2022
CONTENTS
Page
LIST OF TABLES III
INTRODUCTION 1
REVIEWOF LITERATURE 6
1. Effect of Potassium humate on growth
- yield and fruit quality 6
1.1. Effect of Potassium humate on vegetative growth and leaf mineral content
7
1.2. Effect of Potassium humate on yield and fruit quality 9
2. Effect of Magnetic Iron on growth
- yield and fruit quality 10
2.1. Effect of Magnetic Iron on vegetative growth and leaf mineral content
11
2.2. Effect of Magnetic Iron on yield and fruit quality 12
3. Effect of Cobalt on growth
- yield and fruit quality 14
3.1. Effect of Cobalt on vegetative growth and leaf mineral content 15
3.2. Effect of Cobalt on yield and fruit quality 16
4. Effect of Potassium silicate on growth
- yield and fruit quality 18
4.1. Effect of Potassium silicate on vegetative growthand leaf mineral content
20
4.2. Effect of potassium silicate on yield and fruit quality 20
MATERIALS AND METHODS 22
RESULTS AND DISCUSSION 31
First experiment: Effect of soil application with potassium humate & magnetite and cobalt foliar application of mango “Fagri Kalan” cultivar during 2018
- 2019 and 2020 seasons
31
4.1. Vegetative growth parameters 31
4.2. Yield parameters 40
4.3. Fruit quality 44
4.3.1. Fruit physical properties 44
4.3.2. Fruit chemical properties 55
4.4. Leaf mineral content 62
4.5. Leaf chemical properties 82
Second experiment: Effect of soil application with potassium humate & magnetite and potassium silicate foliar application of mango “Fagri Kalan” cultivar during 2018
- 2019 and 2020 seasons
88
4.1. Vegetative growth parameters 88
4.2. Yield parameters 95
4.3. Fruit quality 99
4.3.1. Fruit physical properties 99
4.3.2. Fruit chemical properties 110
4.4. Leaf mineral content 117
4.5. Leaf chemical properties 137
SUMMARY 145
REFERENCES 156
ARABIC SUMMARY



LIST OF TABLES
Table No. Page
1 Physical analysis of the experimental soil 24
2 Chemical analysis of the experimental soil 24
3 Chemical analysis of water used for irrigation 25
4 Effect of soil application with potassium humate & magnetite and cobalt foliar application on the number of new shoots / labeled shoot
- length of new shoot and No. of leaves /new shoot of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 34
5 Effect of soil application with potassium humate & magnetite and cobalt foliar application on the SPAD reading and leaf dry matter of mango “Fagri Kalan” cultivar during 2018
- 2019 and 2020 seasons. 37
6 Effect of soil application with potassium humate & magnetite and cobalt foliar application on the fruit No. /tree and fruit weight of mango “Fagri Kalan” cultivar during 2018
- 2019 and 2020 seasons. 41
7 Effect of soil application with potassium humate & magnetite and cobalt foliar application soil application on yield / tree and yield / feddan of mango “Fagri Kalan” cultivar during 2018
- 2019 and 2020 seasons. 43
8 Effect of soil application with potassium humate & magnetite and cobalt foliar application on the fruit length
- fruit width and fruit shape index of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 45
9 Effect of soil application with potassium humate & magnetite and cobalt foliar application on fruit thickness and fruit volume of mango “Fagri Kalan” cultivar during 2018
- 2019 and 2020 seasons. 48
10 Effect of soil application with potassium humate & magnetite and cobalt foliar application on the peel weight
- seed weight and pulp weight of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 51
11 Effect of soil application with potassium humate & magnetite and cobalt foliar application on the pulp percentage
- pulp / peel Ratio and pulp /seed Ratio of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 54
12 Effect of soil application with potassium humate & magnetite and cobalt foliar application on total sugars
- reducing sugars and non-reducing sugars in fruit of mango “Fagri Kalan” fruit cultivar during 2018 - 2019 and 2020 seasons. 57
13 Effect of soil application with potassium humate & magnetite and cobalt foliar application on total soluble solids
- total acidity and TSS/Acid Ratio in fruit of mango “Fagri Kalan” fruit cultivar during 2018 - 2019 and 2020 seasons. 60
14 Effect of soil application with potassium humate & magnetite and cobalt foliar application and on nitrogen
- phosphorus and potassium content in leaves of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 64
15 Effect of soil application with potassium humate & magnetite and cobalt foliar application on calcium
- magnesium and silicon content in leaves of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 67
16 Effect of soil application with potassium humate & magnetite and cobalt foliar application on zinc
- manganese and copper content in leaves of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 70
17 Effect of soil application with potassium humate & magnetite and cobalt foliar application on boron
- cobalt and iron content in leaves of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 73
18 Effect of soil application with potassium humate & magnetite and cobalt foliar application on sodium and chloride content in leaves of mango “Fagri Kalan” cultivar during 2018
- 2019 and 2020 seasons. 75
19 Effect of soil application with potassium humate & magnetite and cobalt foliar application on Na/K
- Na/Ca and Na/Mg Ratio in leaves of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 78
20 Effect of soil application with potassium humate & magnetite and cobalt foliar application on cobalt content in dry fruit pulp
- peel and fruit pulp dry matter of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 81
21 Effect of soil application with potassium humate & magnetite and cobalt foliar application and on protein
- polyphenol oxidase (PPO) - and peroxidase - (POD) in leave of mango “Fagri Kalan” fruit cultivar during 2018 - 2019 and 2020 seasons. 84
22 Effect of soil application with potassium humate & magnetite and cobalt foliar application on the leaf proline content of mango “Fagri Kalan” cultivar during 2018
- 2019 and 2020 seasons. 86
23 Effect of soil application with potassium humate & magnetite and potassium silicate foliar application on the number of new shoots / labeled shoot
- length of new shoot and No. of leaves/new shoot of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 90

24 Effect of soil application with potassium humate & magnetite and potassium silicate foliar application on the SPAD reading and leaf dry matter of mango “Fagri Kalan” cultivar during 2018
- 2019 and 2020 seasons. 93
25 Effect of soil application with potassium humate & magnetite and potassium silicate foliar application on the fruit No. /tree and fruit weight of mango “Fagri Kalan” cultivar during 2018
- 2019 and 2020 seasons. 96
26 Effect of soil application with potassium humate & magnetite and potassium silicate foliar application soil application on yield / tree and yield / feddan of mango “Fagri Kalan” cultivar during 2018
- 2019 and 2020 seasons. 98
27 Effect of soil application with potassium humate & magnetite and potassium silicate foliar application on the fruit length
- fruit width and fruit shape index of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 101
28 Effect of soil application with potassium humate & magnetite and potassium silicate foliar application on fruit thickness and fruit volume of mango “Fagri Kalan” cultivar during 2018
- 2019 and 2020 seasons. 103
29 Effect of soil application with potassium humate & magnetite and potassium silicate foliar application on the peel weight
- seed weight and pulp weight of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 106
30 Effect of soil application with potassium humate & magnetite and cobalt foliar application on the pulp percentage
- pulp / peel Ratio and pulp /seed Ratio of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 109
31
Effect of soil application with potassium humate & magnetite and potassium silicate foliar application on total sugars
- reducing sugars and non-reducing sugars in fruit of mango “Fagri Kalan” fruit cultivar during 2018 - 2019 and 2020 seasons.
112
32 Effect of soil application with potassium humate & magnetite and potassium silicate foliar application on total soluble solids
- total acidity and TSS/Acid Ratio in fruit of mango “Fagri Kalan” fruit cultivar during 2018 - 2019 and 2020 seasons. 115
33 Effect of soil application with potassium humate & magnetite and potassium silicate foliar application and on nitrogen
- phosphorus and potassium content in leaves of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 119
34 Effect of soil application with potassium humate & magnetite and potassium silicate foliar application on calcium
- magnesium and silicon content in leaves of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 122
35 Effect of soil application with potassium humate & magnetite and potassium silicate foliar application on zinc
- manganese and copper content in leaves of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 125
36 Effect of soil application with potassium humate & magnetite and potassium silicate foliar application on boron
- cobalt and iron content in leaves of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 128
37 Effect of soil application with potassium humate & magnetite and potassium silicate foliar application on sodium and chloride content in leaves of mango “Fagri Kalan” cultivar during 2018
- 2019 and 2020 seasons. 130

38 Effect of soil application with potassium humate & magnetite and potassium silicate foliar application on Na/K
- Na/Ca and Na/Mg Ratio in leaves of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 133
39 Effect of soil application with potassium humate & magnetite and potassium silicate foliar application on cobalt content in dry fruit pulp
- peel and fruit pulp dry matter of mango “Fagri Kalan” cultivar during 2018 - 2019 and 2020 seasons. 136
40 Effect of soil application with potassium humate & magnetite and potassium silicate foliar application and on protein
- polyphenol oxidase (PPO) - and peroxidase - (POD) in leave of mango “Fagri Kalan” fruit cultivar during 2018 - 2019 and 2020 seasons. 139
41 Effect of soil application with potassium humate & magnetite and potassium silicate foliar application on the leaf proline content of mango “Fagri Kalan” cultivar during 2018
- 2019 and 2020 seasons. 141

Thesis 2021

Thesis 2021.

Articles 2021.
   

Thesis 2019

Articles
(vol. 3 Oct 2018) / 18 p.
   

Thesis 2017.
pharmacy - Abstract:
Historically
- plants have been used since ancient times and in folklore for the treatment of many diseases and illnesses including chronic diseases and cancer care. In recent years - plants have been getting more attention as drugs worldwide.
Achillea fragrantissima (Forssk.) Sch. Bip. is a desert plant which belongs to Asteraceae family and is known as Qaysūm in Arabic. We selected it as a member of family Asteraceae to be the plant under investigation. It grows in Sinai
- Egypt and is used in folk medicine by Bedouins for treatment of many diseases. In addition it has been tested for its anticancer activity. The broad aim of this thesis was to conduct a phytochemical investigation and biological confirmation of the plant Achillea fragrantissima (Forssk.) Sch. Bip. and its constituents as an anticancer agents illustrating their mechanism of action.
The initial part of this work focused on large scale extraction of the plant with different solvents
- bioactivity-guided fractionation led to the isolation of seven compounds followed by determination of the chemical nature of them. The isolated compounds are:
The known compounds Eupatilin 7- methyl ether (3)
- chrysosplenol D (4) - Cirsiliol (5) - β-Sitosterol-3-O-β-D-glucoside (6) and Cirsimaritin (7) while Piceol (1) and Veratric acid (2) are reported here for the first time from Achillea fragrantissima (Forssk.) Sch. Bip.
The second part of this work focused on evaluation of the in-vitro cytotoxic activity of the methanolic extract of A. fragrantissima (Forssk.) Sch. Bip
- its fractions and the isolated compounds 1 - 2 - 3 - 4 - 5 and 7 against different cell lines using the Sulpho-Rhodamine-B (SRB) assay. The extract - fractions (4 - 5) and the compounds 3 - 4 - 5 and 7 showed high cytotoxic activities when compared to appropriate reference drug (doxorubicin) and IC50 values (the concentrations of drug required to produce 50% inhibition of cell growth) were calculated for the isolated compounds.
The third part of this work focused on evaluation of the in-vivo antitumor activity of the methanolic extract of A. fragrantissima (Forssk.) Sch. Bip. and its isolated compounds 3
- 4 - 5 and 7 using Ehrlich’s Ascites Carcinoma (EAC) model in mice. A. fragrantissima (Forssk.) Sch. Bip. extract and its isolated compounds reduced the tumor weight compared to EAC-Control group. In addition - the compounds 3 - 7 treatments produced a dose dependent reduction in tumor weight. Determination of serum tumor necrosis factor – alpha (TNF-α) level highlighted that A. fragrantissima (Forssk.) Sch. Bip. extract and its isolated compounds significantly reduced its serum level compared to the EAC-Control group - where 3 - 5 - 7 groups produced a significant reduction in serum level of TNF-α compared to all other groups. Furthermore - A. fragrantissima (Forssk.) Sch. Bip. extract and the isolated compounds significantly increased the total antioxidant capacity (TAC) compared to EAC-Control especially compound 7. The histopathological examination revealed that A. fragrantissima (Forssk.) Sch. Bip. extract and its isolated compounds produced a better differentiation of tumor cells - with reduced nuclear pleomorphism and better formed tubular structures especially with high dose indicating the induction of apoptotic mechanism.
Finally
- an in silico study was performed as a step to elucidate the mechanism of the cytotoxic effect of the compounds isolated from A. fragrantissima (Forssk.) Sch. Bip - where the structure of cirsiliol (5) was docked into the active sites of the crystal structures of PI3K and Akt - two protein kinases that are significantly involved in prostate and breast cancer processes.
Key Words: Achillea fragrantissima (Forssk.) Sch. Bip
- anticancer - Ehrlich’s Ascites Carcinoma - Docking.
Aim of work:
Flora of Egypt especially in Sinai Peninsula is rich and diverse with medicinal and aromatic plants as well as herbs and spices. These plants have been used by local people in folk medicine for curing human and animal illnesses. The plants of genus Achillea as a part of Sinai Peninsula flora were and still a rich source of valuable natural products for treatment of many diseases; therefore
- this study was designed to fulfill:
1. Collection of the plant material from Sinai Peninsula in Egypt.
2. Bioactivity-guided fractionation to isolate active compounds using different chromatographic techniques.
3. Identification and structure elucidation of the isolated compounds
- using 1D NMR - 2D NMR and DEPT measurements.
4. In vitro cytotoxic and in vivo antitumor evaluations of the methanolic extract of Achillea fragrantissima (Forssk.) Sch. Bip. and its isolated compounds.
pharmacognosy

Thesis 2016.


من 2
 







Powered by Future Library Software.All rights reserved © CITC - Mansoura University. Sponsored by Mansoura University Privacy Policy